I am currently an associate professor of surgery and biomedical sciences at Cedars-Sinai. My major research interests are to: develop leading-edge proteomics methods for the proteome-wide analysis of protein abundance, modification and interaction; identify novel, clinically actionable targets for inhibiting cancer metastasis and overcoming tumor resistance to standard therapies; understand the mechanisms of action of the newly discovered drug targets and their inhibitors; develop better and safer cancer therapies and discover novel biomarkers for selecting appropriate patient subpopulations and for monitoring drug response. In the near future, the research will provide personalized therapies to prevent or delay the emergence of metastasis in cancer survivors, and thus enable patients to live much longer and better lives."
- Mechanisms and Targeting of RIPK2 in Cancer Metastasis and Drug Resistance
- Proteome-Scale Analysis of Protein Palmitoylation (S-Acylation)
- Complexome (Interactome) Profiling in Clinical Tissue Specimens
Yan Y, Zhou B, Qian C, Vasquez A, Chatterjee A, Yuan X, Posadas E, Kyprianou N, Knudsen BS, Murali R, Gertych A, You S, Freeman MR, Yang W.
bioRxiv. Posted May 16, 2020.
Zhou B, Wang Y, Yan Y, Mariscal J, Di Vizio D, Freeman MR, Yang W.
Anal Chem. 2019 Aug 6;91(15): 9858-9866.
Zhou B, Yan Y, Wang Y, You S, Freeman MR, Yang W.
Clin Proteomics. 2019 Apr 13;16:15.
Mariscal J, Vager T, Kim M, Zhou B, Chin A, Zandian M, Freeman MR, You S, Zijlstra A, Yang W, Di Vizio D.
J Extracell Vesicles. 2020 Jun 10;9(1):1764192.