Post-Translational Modifications in Alcoholic Liver Disease and Cancer
The primary goal of the Tomasi Laboratory is to understand the role of post-translational modifications in the development and progression of alcoholic liver disease (ALD) and breast and liver cancers. Leading the Tomasi Lab is Maria Lauda Tomasi, PhD. Tomasi is a pioneer in the fields of sumoylation and phosphorylation in ALD, and more than five years ago she began using a proteomic approach to identify the candidate therapeutic targets. The Tomasi Lab is expanding its research to study some key sumoylated players in breast cancer under conditions of alcohol abuse as well. The lab has been using in vivo silencing of targeted proteins to slow the progression of ALD and cancer to limit the development of these diseases.
The Tomasi Laboratory is affiliated with the Cedars-Sinai Department of Medicine.
Maria Lauda Tomasi, PhD, has been working in the field of altered signaling pathways in hepatocellular carcinoma (HCC) for nearly 15 years. She earned her master's degree from University of Southern California (USC) in molecular biology and her doctorate at University of Turin in Italy with highest honors in molecular pathology and oncology. She earned several competitive fellowships from the University of Sassari, Italy, and USC. Tomasi also has an academic appointment as an assistant professor in medicine."
Maria Lauda Tomasi, PhD
- Restoring the Normal Sumoylated Proteins Expression in Alcoholic Liver Disease and Cancer Using a Proteomic Approach In Vivo Model
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Tomasi Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Floris A, Luo J, Frank J, Zhou J, Orrù S, Biancolella M, Pucci S, Orlandi A, Campagna P, Balzano A, Ramani K, Tomasi ML.
J Exp Clin Cancer Res. 2019 Jan 5;38(1):4.
Tomasi ML, Ramani K.
Transl Gastroenterol Hepatol. 2018 Apr 23;3:20.
Tomasi ML, Ramani K, Ryoo M, Cossu C, Floris A, Murray BJ, Iglesias-Ara A, Spissu Y, Mavila N.
FASEB J. 2018 Jun;32(6):3278-3288.
Contact the Tomasi Lab
110 N. George Burns Road
Davis Building, Room 3094A
Los Angeles, CA 90048