Inflammatory bowel diseases (IBD) are characterized by chronic or recurring inflammation of the gastrointestinal tract. IBD is thought to result from an overactive and continuous immune response to intestinal microbiota, including commensal and pathogenic bacteria, in a genetically susceptible host. IBD affects an estimated 1.4 million Americans. The Michelsen Laboratory is studying the underlying mechanisms that lead to the development of chronic inflammatory diseases such as IBD and colon cancer.
The Michelsen Laboratory is affiliated with the Cedars-Sinai F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, the Department of Medicine and the Department of Biomedical Sciences.
Kathrin Michelsen, PhD, is an assistant professor of medicine and research scientist II in the F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute in the Department of Medicine at Cedars-Sinai. She is also an adjunct associate professor at the University of California, Los Angeles, David Geffen School of Medicine.
Kathrin Michelsen, PhD
The Michelsen Laboratory is particularly interested in the role of the innate immune system in the development of inflammatory bowel diseases (IBD). Recent reports have shown that genetic variations in the gene encoding for a tumor necrosis factor family member called tumor necrosis factor-like cytokine 1A (TL1A) confer susceptibility to IBD.
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Michelsen Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Tsuda M, Hamade H, Thomas LS, Salumbides BC, Potdar AA, Wong MH, Nunnelee JS, Stamps JT, Neutzsky-Wulff AV, Barrett RJ, Wang Y, Tang J, Funari VA, Targan SR, Michelsen KS.
Mucosal Immunol. 2019 May;12(3):644-655.
Thomas LS, Targan SR, Tsuda M, Yu QT, Salumbides BC, Haritunians T, Mengesha E, McGovern DP, Michelsen KS.
J Leukoc Biol. 2017 Mar;101(3):727-737.
Zonis S, Pechnick RN, Ljubimov VA, Mahgerefteh M, Wawrowsky K, Michelsen KS, Chesnokova V.
J Neuroinflammation. 2015 Apr 3;12:65.
Contact the Michelsen Lab
8700 Beverly Blvd.
Davis Research Building, Room 4058
Los Angeles, CA 90048