COVID-19 (coronavirus)

Lab Members

Vaishnavi Devarakonda, MS
Graduate Student

I earned my MS from the University of Houston in biotechnology and molecular biology. Later, I joined MD Anderson Cancer Center’s adoptive T-cell department where I worked on TIL therapy in melanoma patients. I then worked at Baylor College of Medicine in the labs of Matthew Ellis, MD, and Meghasyam Kavuri, MD, where we characterized mutations involved in chemotherapy resistance in ER+ breast cancer patients. I’m currently a graduate student in the Merchant Lab and am interested in tumor microenvironment and sentinel lymph node biology in cancer.

Ben Falk, MA
Research Associate IV

Ben Falk has extensive research experience in T-cell-mediated autoimmune diseases and extracellular matrix remodeling. He started working for Dr. Ray Goodwin at the Immunex Corporation in Seattle developing the soluble TNFR and cloning members of the TNF super-family including: CD27L, CD30L, 4-1BB and 4-1BBL. Then he moved to the Benaroya Research Institute to work for Dr. Gerald Nepom studying mechanisms of CD4 T-cell-mediated autoimmune diseases. Later, he followed Dr. Paul Bollyky to Stanford University to continue research on extracellular matrix immunology and inflammation. Recently, he worked on parasite immunity in Chagas heart disease with Dr. David Engman at Cedars-Sinai. He has degrees from the University of Washington (Seattle) and University of Auckland (New Zealand). His primary interest is studying how immune cells modify tissues through extracellular matrix remodeling. Ben is the IMC operator in the mass cytometry core and additionally works on research projects related to IMC mapping of immune cell functions within the tumor microenvironment. 

Joslyn Foley
Research Associate III

Joslyn Foley received her bachelor of science in biochemistry from Worcester Polytechnic Institute. She then worked in the Moormann Lab at the University of Massachusetts Medical School doing longitudinal studies on the role of malaria and Epstein-Barr virus (EBV) co-infections and development of Burkitt lymphoma in Kenyan children in collaboration with Kenya Medical Research Institute. Foley continued doing EBV research at City of Hope, developing a prophylactic and therapeutic virus-like, particle-based EBV vaccine. She is completing her master's degree at Witwatersrand University. At Cedars-Sinai, Foley develops methods for immune system monitoring of leukemia and lymphoma patients enrolled in clinical trial and operates the Helios mass cytometer. She hopes to eventually return to researching infectious diseases with an interest in oncogenic pathogens.

Alicia Gamboa, MS
Graduate student

Alicia Gamboa received her BS in biochemistry from California State University, San Bernardino, and her MS in biochemistry from California State University, Long Beach. She worked under Dr. Katarzyna Slowinska, where she studied the biophysical properties of collagen mimetic peptides and their use for delivery of nucleic acids and small molecule drugs. She then worked at City of Hope as part of a small team for clinical manufacturing of lentiviral vectors. She is now a doctoral student in the Cedars-Sinai Biomedical and Translational Sciences program. She is interested in the role of the immune microenvironment in cancer.

Tucker Lemos
Research Associate I

Tucker Lemos received his bachelor’s degree in biology and English from Williams College. He has worked under David Smith at Isle Royale National Park, where he studied evolutionary plasticity through monitoring changes in the ecological niche of Pseudacris Triseriata. His current research focuses on Hedgehog signaling in hematopoiesis and on exploring related therapeutic targets.

Simeon B. Mahov, MS
Research Bioinformatician II

Mahov's path to bioinformatics began with an interest in numerical methods and control systems theory during his engineering studies at Georgia Tech. His academic pursuits then led him to the Technical University of Munich, Germany, where he specialized in computational science and applied mathematics within the context of biomedical and data science applications. Mahov's background in the latter includes projects of spatio-temporal predictive modeling, as well as inference on multiomic leukemia and lymphoma datasets. In his role at Cedars-Sinai, Mahov aims to support the understanding of, and therapeutic interventions against, cancer by harnessing and developing novel machine-learning approaches toward identifying and characterizing relevant molecular and cellular interactions.

Gangothri Namasivayam, MS
Project Manager

Gangothri Namasivayam is a biotech engineer from India who moved to Los Angeles to pursue her interest in global infectious diseases at the Keck School of Medicine of USC's Master of Science in Global Medicine program. Prior to joining the Merchant Lab, Namasivayam spent her career becoming proficient in the field of regulatory affairs, managing oncology and hematology clinical trials at USC from start to finish. In her current role at Cedars-Sinai, she coordinates and oversees research projects in the Merchant Lab, as well as aids in design and development of investigator-initiated clinical trials, including results from data analyzed from preclinical studies performed in the lab.

Noah Merin, MD, PhD
Assistant Professor of Medicine

Noah Merin, MD, PhD, is a hematologist treating patients with hematologic malignancies, and performs allogeneic stem cell transplantation. Together with the Merchant Lab, Merin has developed a novel haploidentical stem cell transplantation regimen that uses reduced-intensity chemotherapy, post-transplant cyclophosphamide graft-versus-host disease prophylaxis, pre-emptive donor-derived natural killer cell add-back, and omission of drugs that inhibit immune recovery. This approach is reducing rates of graft versus host disease and viral reactivation, and may lead to improved outcomes. Merin is collaborating with the Merchant Lab to study the reconstitution of the immune system following allogeneic stem cell transplantation. Improved stem cell transplant regimens, and greater insight into post-transplant immune reconstitution, will lead to better clinical outcomes for patients undergoing this life-saving procedure. Merin and Merchant are also collaborating on a clinical trial of a bispecific T cell engager, blinatumomab, combined with haploidentical donor lymphocyte infusions, for patients with B-cell acute lymphoblastic leukemia. One goal of this project is to study the spatial clustering of T cells in the bone marrow as a marker of treatment response.

Nathan Punwani, MD
Assistant Professor of Medicine

Nathan Punwani, MD, has clinical interests in myeloid malignancies and bone marrow failure disorders such as acute myeloid leukemia and myelodysplasia. He is interested in research into the bone marrow microenvironment and the inflammatory preconditions that precipitate bone marrow disorders. Punwani also has a passion for health services outcomes and cost research. He is working with the Merchant Lab to help translate laboratory discoveries into innovative clinical trials. 

Alex Xu, PhD
Project Scientist

Alex Xu is a reformed materials scientist with an interest in single cell analysis and cancer heterogeneity. After studying virus templated materials and the EGFR signaling pathway at MIT, he developed a nanoscale drug delivery platform during his PhD at Stanford University. As a postdoc at Caltech and the Institute for Systems Biology, he applied single cell transcriptomics to projects in cancer and, more recently, COVID-19. At Cedars-Sinai, he is interested in spatial, high-dimensional, multi-omic analyses of disease.

Alumni Lab Members

B. Devi Chinthirla, PhD
Research Associate II

Devi Chinthirla, PhD, has expertise in immunohistochemistry and confocal microscopy. Her experience in immunohistochemistry assists in the validation of antibodies that are used in multiplex imaging mass cytometry to study the immune microenvironment in cancer. 

Anthony R. Colombo, BS

Anthony R. Colombo is an applied mathematician and a graduate biostatistics student. He is completing his master's degree. Colombo develops computational biological models describing the intersection between the cancer genome and micronenvironment.

Madison Davis, MS
Research Associate III

Madison Davis received her master of science degree in biochemistry and molecular biology at Oregon Health and Science University under the guidance of Peter Zuber, PhD. While in the Zuber Lab, Davis' research focused on the global transcriptional regulator Spx and the amino acid residues that are essential for its binding to the αCTD region of RNA polymerase. She was previously in the lab of Stephen Shiao, MD, PhD, where her research focused on the use of checkpoint inhibitors and radiation therapy in various cancer types both in clinical trials and mouse models. Davis is currently investigating possible therapeutic targets for myeloproliferative neoplasms, primarily focusing on hedgehog signaling and its downstream transcription factors. 

Eman Farghal, MD
Visiting Postdoctoral Fellow

Eman Farghal, MD, earned a bachelor's degree in medicine, master's degree in clinical pathology and her medical degree in clinical pathology (hemato-oncology) from Tanta University, Egypt. Farghal completed a molecular and computational biology fellowship at the University of Southern California. Her research interests include studying the immune microenvironmental changes in patients with myelofibrosis using the imaging mass cytometry technology and genetic assessment of mutational effects on disease management as well as targeting personalized medicine using next generation sequencing technology.

Monirath Hav, MD, PhD
Project Scientist

Monirath Hav, MD, PhD, is a trained histopathologist who brings her experience in tissue diagnostics and immunohistochemistry to study the immune microenvironment in cancer. Her research uses the highly multiplex imaging mass cytometry platform.

Contact the Merchant Lab

127 S. San Vicente Blvd.
Pavilion, A8700
Los Angeles, CA 90048