The Melmed Laboratory focuses on elucidating mechanisms of pituitary tumor development and pathogenesis, translating the study of anterior pituitary function regulation to the clinic and establishing new modalities of diagnosis and treatment for pituitary diseases. Examples of work in the Melmed Lab include acromegaly therapeutic targeting via somatostatin receptor signaling, Cushing disease drug discovery using a zebrafish model for screening of small molecules, and characterization of the human pituitary tumor-transforming gene, critical to pituitary tumor cell cycle outgrowth.
The Melmed Laboratory is affiliated with the Medicine Department and Pituitary Center.
The Melmed Laboratory focuses on pathogenesis and treatment of pituitary tumors, integrating basic science discovery with prospective clinical study of patients with pituitary disease. The clinical and translational training in the Pituitary Center and Melmed Laboratory are ideal nurturing environments for scholarly creativity in pituitary medicine.
Collaborations & Resources
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Melmed Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Ben-Shlomo A, Deng N, Ding E, Yamamoto M, Mamelak A, Chesnokova V, Labadzhyan A, Melmed S
J Clin Invest. 2020;130(11):5738-5755
Chesnokova V, Zonis S, Zhou C, Recouvreaux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA, Uhart M, Melmed S
Proc Natl Acad Sci USA. 2016;113(23):E32590-32599
Liu NA, Araki T, Cuevas-Ramos D, Hong J, Ben-Shlomo A, Tone Y, Tone M, Melmed S
J Clin Endocrinol Metab. 2015;100(7):2557-2564
Fukuoka H, Cooper O, Ben-Shlomo A, Mamelak A, Ren SG, Bruyette D, Melmed S
J Clin Invest. 2011;121(12):4712-4721