Research Areas

The McGovern Laboratory, or Translational Genomics Group (TGG), is involved in studies to identify additional susceptibility genes in European populations as well as to identify genes associated with inflammatory bowel diseases (IBD) in the Puerto Rican, Asian, Ashkenazi Jewish and African American populations. The identification of these genes leads to a greater understanding of the underlying processes and causes that lead to IBD.

In addition, the TGG is interested in how genetic variants are associated with different manifestations of IBD including disease severity and response to therapy. Collectively, these genetic data, together with other data including clinical parameters will facilitate the move toward a more personalized approach to clinical medicine.

GRAIL network for all known IBD genes with p < 0.05. (Figure adapted from Jostins L et al. Nature 2012. )

Repository and Database

To facilitate our research and that of other groups, both within and outside the F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, the TGG also manages the Mucosal Immunology Repository for Inflammatory And Digestive Diseases (MIRIAD) IBD database and research repository. The IBD database allows us to consolidate demographic, clinical, genomic and other datasets, greatly enhancing our ability to perform research. The database also keeps a record of samples collected in our repository, thereby linking biospecimens to both clinical and genomic data. Patients with IBD attending the IBD center's clinics and endoscopy units, and for surgery, are approached to see if they want to contribute samples to the IBD repository.


Biostatistics has become an increasing part of our group's research as we generate large data across many different platforms. Our group is interested in developing new analytic methods for integrating and analyzing these data.

Contact the McGovern Lab

110 George Burns Rd.
Davis Building, Rooms 4094 A, B
Los Angeles, CA 90048

8730 Alden Dr., Suite E244
Los Angeles, CA 90048