Thrombosis Within Cardiac Chambers
Thromboembolic complications are a significant cause of morality and re-hospitalization in heart failure patients. One potential source of thrombi is the endocardial endothelial surface of the heart. The Hasan Lab is interested in understanding how nerve-endothelial interactions are dysregulated in heart failure, resulting in a compromised endothelium and increased propensity for thrombus formation.
Cardiac Arrhythmias and Aberrant Cardiac Nerves
Arrhythmias can cause clots to form and result in sudden cardiac death. One potential mechanism for arrhythmia generation is heterogeneous nerve patterning and activity. The Hasan Laboratory is interested in understanding the mechanisms for this aberrant nerve patterning in pathological states such as obesity and heart failure.