The Grivennikov Laboratory actively studies immunology, microbiota, tissue microenvironment and cancer using various animal models, organoids and an array of modern technologies, including genomics, metabolomics, reverse mouse genetics, imaging and others. The overarching goals of the Grivennikov Lab are to decode new inflammatory, immune and microenvironmental mechanisms governing tumor microenvironment, tumor promotion and resistance to therapies, tissue regeneration and homeostasis. In our research, we work with models of intestinal inflammation, gastrointestinal cancers and study the effects of microbiota, inflammation and microbial metabolites. Traditional lab interests include studies of cell-type-specific cytokine signaling in inflammation; however, we actively continue expanding our research interests and portfolio.
Currently, the main research direction in the lab, includes:
- Role of cytokine pathways and inflammation in inflammatory bowel disease and colon cancer
- Role of functional microbiota in induction of inflammation, tumorigenesis and cancer metastasis
- Role of tumor microenvironment in the progression of colon and pancreatic cancers
Sergei Grivennikov, PhD, obtained his doctorate at Engelhardt Institute of Molecular Biology in Moscow and trained at National Cancer Institute/National Institutes of Health and University of California, San Diego, before joining Fox Chase Cancer Center in 2012 and finally establishing his Grivennikov Lab at Cedars-Sinai.
- Tumor-Elicited Inflammation
- Role of Cytokine Pathways and Inflammation in Inflammatory Bowel Disease and Colon Cancer
- Role of Functional Microbiota in Induction of Inflammation, Tumorigenesis and Cancer Metastasis
- Role of Tumor Microenvironment in Progression of Colon and Pancreatic Cancers—Tumor Promotion and Sensitivity to Immunotherapies
- Inflammation and Cytokines in Tissue Injury and Regeneration
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Grivennikov Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Andreeva NV, Gabbasova RR, Grivennikov SI
Curr Opin Microbiol. 2020 Aug;56:118-126
Greten FR, Grivennikov SI
Immunity. 2019 Jul 16;51(1):27-41
Dmitrieva-Posocco OS, Dzutsev A, Posocco D, Hou V, Yuan W, Thovarai V, Mufazalov IA, Gunzer M, Shilovskyi IP, Khaitov MR, Trinchieri G, Waisman A, Grivennikov SI
Immunity. 2019 Jan 15;50(1):166-180.e7