The Freeman Laboratory focuses on urogenital tract physiology, with a primary focus on cancer progression from onset to lethal disease. Prostate cancer is an area of strong emphasis. We also have an interest and substantial publication history in bladder cancer, breast cancer, smooth muscle regulation and dysfunction, and interstitial cystitis/pelvic pain syndrome.
The Freeman Laboratory is affiliated with the Samuel Oschin Comprehensive Cancer Institute and Surgery Department.
- Lipid metabolism and points of intersection of metabolic pathways with oncogenic signal transduction mechanisms
- The role of circulating cholesterol in prostate cancer cell growth and survival and opportunities for inhibition of disease progression using cholesterol targeting strategies
- Tumor cell plasticity, particularly the origin and significance of the poorly understood amoeboid tumor cell phenotype
- Chromatin structure in relation to androgen receptor function, lipid metabolism and metabolic pathways
- The role of bioactive extracellular vesicles ("oncosomes") produced by tumor cells and the profiling of these particles for the purpose of developing biomarker signatures that report tumor characteristics and response to therapy
- Quantitative mass spectrometry-based proteomics as a means of studying signal transduction and biomarker discovery.
Rotinen M, You S, Yang J, Coetzee SG, Reis-Sobreiro M, Huang WC, Huang F, Pan X, Yáñez A, Hazelett DJ, Chu CY, Steadman K, Morrissey CM, Nelson PS, Corey E, Chung LWK, Freedland SJ, Di Vizio D, Garraway IP, Murali R, Knudsen BS, Freeman MR.
Nat Med. 2018 Dec;24(12):1887-1898.
Reis-Sobreiro M, Chen JF, Novitskaya T, You S, Morley S, Steadman K, Gill NK, Eskaros A, Rotinen M, Chu CY, Chung LWK, Tanaka H, Yang W, Knudsen BS, Tseng HR, Rowat AC, Posadas EM, Zijlstra A, Di Vizio D, Freeman MR.
Cancer Res. 2018 Nov 1;78(21):6086-6097.
Sharma NV, Pellegrini KL, Ouellet V, Giuste FO, Ramalingam S, Watanabe K, Adam-Granger E, Fossouo L, You S, Freeman MR, et al.
Cancers (Basel). 2018 Oct 11;10(10). pii: E379.
Contact the Freeman Lab
8700 Beverly Blvd.
Davis Building, Room 5069
Los Angeles, CA 90048