Being able to quantify proteins and their post-translational modifications (PTMs), together with neo-epitope generation driven by PTM is my lab goal in the near future. Each modification results from a specific local physiological or pathobiological process. Identification of each modification, and the affected tissue-specific protein, may produce a unique disease-specific biochemical marker. Particularly, PTM, called citrullination and neo-epitopes to citrullinated sites in recent years have become increasingly appreciated. Our central philosophy is that such neo-epitopes can be utilized in translational medicine to estimate safety and efficacy in both preclinical models and clinical settings."
- Essential Cross-Talk Between Cardiomyocytes, Fibroblasts and Inflammatory Cells Through Citrullinoproteome Modulation
- New Markers for Pathogenesis of Ischemic and Nonischemic Heart Diseases in Rheumatoid Arthritis
- Mechanisms Underlying the Atherosclerosis Plaque Development
Meet Our Team
Our shared passion is to decipher the role of protein arginine deiminases and citrullinated proteins within physiological and pathological conditions using advanced mass spectrometry encompassing molecular and cellular biology. We celebrate our different backgrounds and strengths, help each other with our weaknesses and together we create an environment of lively interaction and mutual respect.
The candidate will investigate whether citrullinated proteins or antibodies to citrullinated proteins can be used as biomarkers for the early detection of many diseases, including rheumatoid arthritis, cancer and Alzheimer's disease.
The Fert-Bober Laboratory has a current opening for a Postdoctoral Scientist. This position will investigate molecular mechanisms of cardiovascular development, regeneration and cardiac fibrosis using mass spectrometric-based proteomics methods for the study of proteins and their roles in cellular signaling events.
Research Associate I
The Fert-Bober Laboratory has a current opening for a Research Associate I. The position will pursue cutting-edge research pertaining to cellular and molecular mechanisms from inflammation to fibrosis in various cardiac disease with primary focus on post-translational modification, citrullination.
Fert-Bober J, Darrah E, Andrade F.
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