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Erbay Laboratory

Headshot of Ebru Erbay, MD, PhD
Personal Statement

I received my MD degree from Ankara University and PhD in cell and structural biology from the University of Illinois, Urbana-Champaign. I have been working on cellular adaptation to nutrient stress since my doctoral studies, which focused on mTOR signaling. My postdoctoral studies with Gökhan S. Hotamışlıgil at the Harvard School of Public Health demonstrated the causality of endoplasmic reticulum (ER) stress to hyperlipidemia-induced inflammation and atherosclerosis. Studies published from my lab further demonstrated that highly specific, small molecule modulators of ER's stress responses can reduce atherosclerosis progression. We are a highly collaborative group that works with experts in diverse fields and utilizes the state-of-the-art research technologies to uncover ER's contribution to cellular homeostasis and stress, with a specific focus on immune cells and in cardiovascular syndrome.


Ebru Erbay, MD, PhD

Researchers in the Erbay Lab are exploring the contribution of endoplasmic reticulum and mitochondrial stress in immune cells to atherosclerosis development and progression. We have found that reducing endoplasmic reticulum stress is important in preventing atherosclerotic disease.
Collaborations & Resources

Meet Our Team

Job Openings

Ona UI, Yildirim AD, Tufanli O, Cimen I, Kocaturk B, Hamid SM, Chen S, Sin J, Shimada K, Shah PK, Gottlieb RA, Arditi M, Erbay E.

J Am Coll Cardiol. 2019 Mar 19;73(10):1149-1169.

Tufanli O, Telkoparan-Akillilar P, Acosta-Alvear D, Kocaturk B, Cimen I, Onat UI, Hamid SM, Walter P, Weber C, Erbay E.

Proc Natl Acad Sci USA. 2017 Feb 21;114(8):E1395-E1404.

Çimen I, Kocatürk B, Koyuncu S, Apaydın O, Tufanlı Ö, Onat UI, Demirsoy Ş, Aykut GZ, Nguyen UT, Watkins SM, Hotamışlıgil GS, Erbay E.

Sci Transl Med. 2016 Sep 28;8(358):358ra126.

Erbay E, Babev VR, Mayers JR, Makowski L, Tape KN, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS.

Nat Med. 2009 Dec;15(12):1383-1391.

Contact the Erbay Lab

If you have any questions or would like more information about the research work at the Erbay Laboratory, please give us a call.

Advanced Health Sciences Pavilion, Room A9104
127 S. San Vicente Blvd.
Los Angeles, CA 90048