The Chen Laboratory is unraveling basic mechanisms of lung injury and repair. Our focus is on how lung epithelial cells interact with other cellular compartments and with the extracellular matrix to regulate inflammatory cell recruitment and lung fibrosis in various cell-based and animal models.
The Chen Laboratory is affiliated with the Department of Medicine and Women's Guild Lung Institute.
I have had a long-standing interest in the lung epithelial response to injury and how aberrant responses acutely lead to lung injury and chronically promote pathological outcomes such as lung fibrosis. The initial work from my laboratory focused on epithelial interactions with the matrix identifying specific mechanisms regulating re-epithelialization. More recently, my research group has investigated mechanisms by which the lung mucosal immunity regulates acute lung injury after infectious insults."
- COVID-19 mechanisms and therapeutics
- Dysbiosis and post-influenza MRSA infection
- Syndecan-1 and influenza infection
- Syndecan-1 and lung fibrosis
- Dynactin-4 polymorphisms and pseudomonas colonization in cystic fibrosis
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Chen Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Gottlieb RL, Nirula A, Chen P, Boscia J, Heller B, Morris J, Huhn G, Cardona J, Mocherla B, Stosor V, Shawa I, Kumar P, Adams AC, Van Naarden J, Custer KL, Durante M, Oakley G, Schade AE, Holzer TR, Ebert PJ, Higgs RE, Kallewaard NL, Sabo J, Patel DR, Klekotka P, Shen L, Skovronsky DM.
JAMA. 2021 Feb 16;325(7):632-644.
Yao C, Bora SA, Parimon T, Zaman T, Friedman OA, Palatinus JA, Surapaneni NS, Matusov YP, Cerro Chiang G, Kassar AG, Patel N, Green CER, Aziz AW, Suri H, Suda J, Lopez AA, Martins GA, Stripp BR, Gharib SA, Goodridge HS, Chen P.
Cell Rep. 2021 Jan 5;34(1):108590
Chen P, Nirula A, Heller B, Gottlieb RL, Boscia J, Morris J, Huhn G, Cardona J, Mocherla B, Stosor V, Shawa I, Adams AC, Van Naarden J, Custer KL, Shen L, Durante M, Oakley G, Schade AE, Sabo J, Patel DR, Klekotka P, Skovronsky DM
N Engl J Med. 2021 Jan 21;384(3):229-237.