I trained in structure-function biology of luteinizing hormone-receptor interactions, and went on to identify how stromal fibroblasts and associated cancer cells communicate via transforming growth factor-ß signaling. These experiences have helped our laboratory identify targets for intervention that can serve to support sensitivity to current cancer cell targeted therapies. Applications of these concepts have resulted in testing in cytokine and metabolic regulators in clinically relevant animal models of prostate, lung, renal, colon, pancreatic and bladder cancer. We are excited about the cross-disciplinary collaborations that have enabled us to interrogate signaling mechanisms and therapeutic development for cancer patients.
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Bhowmick Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Haldar S, Mishra R, Billet S, Thiruvalluvan M, Placencio-Hickok V, Madhav A, Duong F, Angara B, Agarwal P, Gottlieb R, Tighiouart M, Posadas EM, Bhowmick NA.
Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8515-8523.
Mishra R, Haldar S, Placencio-Hickok V, Madhav A, Rohena-Rivera K, Agarwal P, Duong F, Angara B, Tripathi M, Liu Z, Gottlieb RA, Posadas EM, Wagner S, Bhowmick NA.
J Clin Invest. 2018 Oct 1;128(10):4472-4484.
Kiskowski MA, Jackson RS II, Banerjee J, Li X, Kang M, Iturregui JM, Franco OE, Hayward SW, Bhowmick NA.
Cancer Res. 2011 May 15;71(10):3459-70.
Boomershine CS, Chamberlain A, Kendall P, Afshar-Sharif A-R, Huang H, Washington MK, Lawson WE, Thomas JW, Blackwell TS, Bhowmick NA.
Gut. 2009 Sep;58(9):1267-74.