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Skeletal Program


Human stem cells, isolated from bone marrow, home to a fractured and osteoporotic vertebra.


The Skeletal Program isolates adult stem cells from bone marrow or adipose tissue, and then matures these cells into the desired cell type for injection into an injured area. This stem cell technology has already proven effective in repairing complex fractures in the vertebrae, skull, jaws and long bones, as well as torn tendons and injured intervertebral discs.

Osteoporosis-related vertebral compression fractures account for approximately 700,000 injuries and billions of healthcare dollars in the United States each year. Patients with an osteoporosis-related vertebral compression fracture have a deceased number of bone marrow-derived mesenchymal stem cells (MSCs), or dysfunctional MSCs, or both.

Most recently, the Skeletal Program theorized that injection of MSCs, combined with parathyroid hormone (PTH, which is already approved by the FDA for the treatment of osteoporosis), could be an effective therapy for the treatment of multiple fractures.

This research has shown that in animals with osteoporosis and vertebral fractures treated with intravenous injections of MSCs and PTH, we could detect enhanced MSC homing to the fracture sites, leading to rapid bone repair.

Our next step in this research is to conduct clinical trials that utilize MSCs for rapid fracture repair and disc regeneration. Should this treatment protocol prove successful, it could significantly shorten hospitalization time and offer a minimally invasive solution for osteoporosis and its related fragility fractures.


Dan Gazit, DMD, PhD
Zulma Gazit, PhD
Dmitriy Sheyn, PhD
Wafa Tawackoli, PhD
Collaborative Research

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Board of Governors Regenerative Medicine Institute
Pavilion, Eighth Floor
8700 Beverly Blvd.
Los Angeles, CA 90048

Fax: 310-248-8066