Determinants of Liver Metastasis Program
The four projects examines different aspects of liver disease, but study overlapping signaling pathways common to the support or metastatic
Explores the acquisition of features that enable metastasis from circulating saturated fat and endoglin signaling in hepatocytes and cancer epithelia.
Examines the pro-metastatic impact of hepatic stellate cell (HSC)-derived hyaluronic acids in non-alcoholic fatty liver disease.
Studies the regulation and contribution of yes-associated protein (YAP) in creating a pro-metastatic liver microenvironment through the activation of a pro-cancer phenotypes of HSCs and macrophages.
Investigates the roles of methionine adenosyltransferase (MAT) proteins in liver metastasis, from the loss of protective MAT1A to the pro-cancer elevated expression of MAT2A and MAT2B.