The Breast Oncology Disease Research Group is a multidisciplinary program, conducting early and late-phase clinical trials to improve the lives of patients with breast cancer. Our research program focus is wide-ranging and includes innovative surgical techniques, novel treatments and cutting-edge translational research to develop new treatment options and improve clinical outcomes.
Novel immune combinations are needed to harness the immune system to recognize and fight early stage breast cancer. Combining radiation therapy (RT) with checkpoint in the preoperative setting while the tumor is intact is one such combination. RT-induced tumor cell death increases the supply of tumor-specific antigens and leads to the release of signaling molecules that attract immune cells to the tumor microenvironment. The addition of checkpoint blockade to RT might synergistically enhance its antitumor response. The purpose of this trial is to test the safety and immunogenicity of this approach with the eventual goal of improving long-term cure rates in high-risk early breast cancer.
Meet the Team
Meet the multidisciplinary of dedicated clinicians and investigators who collaborate to further our understanding, diagnosis and treatment of breast cancer.