Center for Integrated Research in Cancer and Lifestyle
CIRCL relies on professional participation in three disciplines—epidemiology, basic science and clinical trials—to ensure scientific rigor in its studies. These disciplines work together to generate concepts, data and discussion that challenge and strengthen hypotheses and propel the science forward. CIRCL currently has studies underway investigating pancreatic, brain, breast, liver and prostate cancers.
The CIRCL team of epidemiologists observes the interactions and correlations between lifestyle patterns, cancer incidence and progression, to develop hypotheses about the role of various lifestyle factors across multiple cancer types. These include lifestyle factors that may influence cancer disparities in minority populations and races. One recent project focused on understanding how inflammation caused by dietary carcinogens may be partly responsible for disproportionally higher prostate cancer incidence and mortality rates in the African American population. Other projects investigate the role of diet and microbiome in development of inflammation often leading to liver cancer, especially among Hispanics.
The CIRCL basic science team investigates the molecular mechanisms by which lifestyle factors, including diet, exercise and stress influence tumor growth. Recent projects include the first in-depth analysis of diet-related prostate tissue inflammatory markers and whether they are modified by race, the impact of obesity on pancreatic cancer development and whether carbohydrate quality, in addition to quantity, affects cancer growth.
It is clear that genes load the gun but lifestyle pulls the trigger. Now we just need to figure out how to un-pull the trigger.
Warschaw Robertson Law Families Chair in Prostate Cancer
Director, Center for Integrated Research in Cancer and Lifestyle
Co-Director, Cancer Genetics and Prevention Program
Associate Director, Faculty Development Samuel Oschin Comprehensive Cancer Institute
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